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Canine cancer is a leading cause of canine deaths, often resulting from complex interactions between germline-risk genetics, somatic mutations, and environmental exposures. To help identify major dietary, gene...
Cancer is driven by acquired genetic aberrations that drive the cellular cancer phenotype. In addition, hereditary genetic risk factors play a central role explaining the large difference in cancer risk betwee...
Comparative oncology is the study of naturally-occurring cancer in companion (pet) animals, mainly dogs, and is a powerful tool in cancer research and drug development. Comparative oncology clinical trials are...
Canine cutaneous mast cell tumors (MCTs) are a common, yet clinically challenging tumor type given their variable biological behavior. Although patients with low grade MCTs can often be effectively managed wit...
Immunotherapeutic approaches to cancer treatment have gained significant traction in recent years, due in large part to the success of immune checkpoint inhibitors and T cell-based therapies. Comparative oncol...
The original article was published in Veterinary Oncology 2024 1:10
Oral tumours are common in dogs and cats. When surgery is not an option, medical treatment including chemotherapy, radiotherapy or electrochemotherapy (ECT) can be used. This case report describes an inoperabl...
Recent years have shown a substantial increase in minimally invasive procedures for the management of cancer in human patients, owing to the potential for improved perioperative outcomes and the demonstration ...
Recent years have shown a substantial increase in minimally invasive procedures for the management of cancer in human patients, owing to the potential for improved perioperative outcomes and the demonstration ...
Erythema multiforme is a rare immune-mediated cutaneous disorder. Canine erythema multiforme (EM) can occur secondarily to triggers such as drugs, food and infections but is more commonly considered idiopathic...
Dog have been trained to detect a variety of human cancers. However, studies examining their ability to find canine cancer are sparse and show variable results. Whilst dogs were shown to be successful at detec...
Thyroid carcinoma is a rare malignancy in middle-aged to older, medium to large breed dogs. Most are carcinomas or adenocarcinomas and are often detected incidentally via palpation or advanced imaging, such as...
Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder malignancy in dogs, but the treatments used in the clinic are relatively ineffective for most of them. Dogs represent a naturally-...
L-Asparaginase (ASNase) exerts its main anticancer activity by depleting L-Asparagine (Asn). In dogs with lymphomas, ASNase is commonly administered intramuscularly or subcutaneously and incorporated in multia...
The Correction to this article has been published in Veterinary Oncology 2025 2:6
Successful management of advanced anal sac gland adenocarcinomas (AGASACA) often requires a multimodal approach. In recent years the role of palliative radiotherapy (pRT) has become increasingly more important...
Intradural lipomas have been previously reported in individuals with spinal dysraphism; however, they have not been reported in cats with an intact spinal canal. Desmoid tumors are a rare finding in veterinary...
Hypertrophic osteopathy (HO) is a paraneoplastic syndrome, and the most notable cause in dogs is pulmonary metastatic osteosarcoma (OSA). Although many molecular factors in canine OSA have been shown in metast...
The most common first-line treatment for canine lymphoma is a chemotherapy protocol that includes cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Canine high-grade T-cell lymphoma has been f...
The high incidence of nodal metastasis, variable lymphatic drainage patterns, and prognostic significance of nodal metastasis in dogs with apocrine gland anal sac adenocarcinoma (AGASACA) highlight the need fo...
Appendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, ran...
Non-resectable tumors of the head can represent a therapeutic challenge in dogs and prognostic indicators and markers of response to treatment are needed. Tumor microenvironment, in particular microvascular de...
The authors report on the rare occurrence of dual synchronous primary brain tumors in a canine patient, successful treatment with radiation therapy, and medical therapy with patient stabilization for almost th...