Table 4 Selected publications characterizing somatic mutations in canine tumors
From: Genetics of canine cancer: a guide for the veterinary oncologist
Author | Cancer / Tumor type (number of tissues) | Method | Recurrently mutated genes |
|---|---|---|---|
Amin 2021 [70] | Glioma (83) | WES/WGS | PDGFRA, PIK3CA, NF1 |
Arendt 2023 [8] | Mammary tumors (55) | WES | PIK3CA, MUC1, KRAS, TTN, NLRP5, ENSCAFG00000038503, ARID1A |
Das 2023 [71] | Soft tissue sarcomas (29) | WES | TP53, KMT2D |
Elvers 2015 [10] | B and T- cell lymphoma (105) | WES | T-cell: PTEN, SATB1, MAP2K1, PSMA1, COX8A, LTA4H, TBC1D26, PTPN6, NLRP5, GLUD2, KRTAP10-6, ENSCAF00000031638 B-cell: FAM90A1, DDX3X, TRAF3, PSMA1, POT1, FBXW7, TP53, PNRC1, TBC1D26, RPL23A, SETD2, ENSCAFG00000031638 |
Gardner 2019 [72] | Osteosarcoma (37) | WES/WGS | TP53, SETD2, RPL27A, MLLT10 |
Gianuzzi 2022 [73] | Diffuse large B-cell lymphoma (77) | WES | TRAF3, SETD2, POT1, TP53, MYC, FBXW7, DDX3X, TBL1XR1, MAP3K14, ENSCAFG00000046771, PHC3, ABCA13, CIC, LRP1B, TTN, RARA, PIK3CD, H3C8, EHD3, GBE1, VWF, DIAPH2, FAM50A, GADD45A, SYNE1, THBS2, PLEC, ETV1, HIVEP3, MYT1L, LRRN3, MEF2C, ATXN1, KIF21A, TLR5, FSIP2, KDM6A, TRRAP, SYNE2, SUZ12, LAMA1, ANKRD11, LRRIQ1 |
Kim 2020 [74] | Mammary tumors (143 malignant + 40 benign) | WES | PIK3CA, KRAS, MKI67, TP53, NKX1-2, SETD1A, PTEN, PIK3R1, AKT1 |
Lee 2019 [75] | Mammary tumors (20) | WES | PIK3CAa, PRMT3, cOR8S14, ENSCAFG00000020185, ENSCAFG00000029433, BHLHA9 |
Lorch 2019 [76] | Pulmonary carcinoma (5) Additional 73 tumors and 10 cell lines captured by small selected array) | WES (5 dogs) | HER2, TP53, PTENa |
Megquier 2019 [77] | Hemangiosarcoma (47) | WES | TP53, PIK3CAa, PIK3R1, ORC1, RASA1, ARPC1A |
Sakthikumar 2019 [9] | Osteosarcoma (66) | WES | TP53, SETD2, TANGO2, LOXHD1, MYT1L |
Saffari 2019 [78] | Ameloblastoma (16) | WES | HRAS |
Thomas 2023 [79] | Urothelial cell carcinoma (8 BRAF p.V595E + , 28 BRAF p.V595E -) | WES | BRAF, MAP2K1, LRP1B, SMCHD1, ARID1A, CSMD3, KDM5C, CSMD1, RYR2, KMT2D, STAG2, MSH6, PBRM1, ATM, MDC1, |
Wang 2017 [68] | Hemangiosarcoma (20) | WES | TP53, PIK3CA |
Wong 2019 [62] | Oral malignant melanoma (65) | WES | NRAS, TP53, RP1, FAT4, PTPRJ, CSMD3 |
Wong 2023 [80] | Urothelial cell carcinoma (87) | WES | BRAF, TTN, ZFHX4, CSMD3, FSIP2, CDH12, USH2A, LRP1B, HMCN1, ARID1A, PCDH17, HMCN2, TNNI3K, MGAM2, LRP2, ENSCAFG00000007873, KDM6A, LAMA2, FLNA, MDN1, GRIK2, COL11A1, VCAN, XIRP2, ZNF536, ZNF804B, TENM3, DNAH7, PCDH9 |